MB1 Labs Peptides

Anxiolytic Heptapeptide

Calm Without Sedation: The Tuftsin Analog That Matches Benzodiazepines

Selank is a synthetic heptapeptide analog of tuftsin (sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro) engineered for enhanced metabolic stability. In clinical trials for generalized anxiety disorder, Selank matched the anxiolytic efficacy of medazepam (a benzodiazepine) while adding anti-asthenic and psychostimulant benefits — without sedation, cognitive impairment, or dependence potential. This unique "calm yet clear" profile makes it central to anxiety and cognition research.

  • Heptapeptide: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
  • Tuftsin analog with glyproline motif for stability
  • Anxiolytic efficacy comparable to benzodiazepines
  • No sedation, amnesia, or dependence potential
  • Anti-asthenic (energy-boosting) properties
Multi-Axis Mechanism

How Selank Achieves Anxiolysis Without Trade-Offs

Selank operates through a rare multi-system mechanism. It modulates 52 GABA-related genes, increases hippocampal BDNF, and inhibits enkephalin-degrading enzymes (IC₅₀ ~20 µM) — prolonging the body's natural anti-stress peptides. Unlike benzodiazepines that directly enhance GABA receptor activity, Selank changes receptor affinity through gene expression, explaining its synergy with classical anxiolytics and lack of tolerance development.

  • Modulates 52 genes related to GABA signaling
  • Increases BDNF in hippocampus (intranasal-confirmed)
  • Inhibits enkephalinases (preserves endogenous anti-stress peptides)
  • Regulates IL-6 and 34 inflammation-related genes
  • Alters GABA receptor affinity (not direct agonism)
Research Applications

From Memory Enhancement to Pain Modulation

Selank research extends far beyond anxiety. Studies demonstrate enhanced memory trace stability independent of anxiety reduction — suggesting direct nootropic properties. It modulates 36 hippocampal genes encoding plasma membrane proteins involved in learning. Pain research shows enkephalinase inhibition helps protect natural analgesic peptides. Additional applications include immune modulation, cognitive rescue after brain injury, and even antiviral activity against influenza A.

  • Memory and learning: Enhanced trace stability, 36 hippocampal genes
  • Pain modulation: Enkephalinase inhibition preserves natural analgesia
  • Cognitive rescue: Restores function after neurotoxin damage
  • Immune modulation: IL-6 suppression, 34 cytokine-related genes
  • Antiviral research: Activity against influenza A/H3N2

MB1 LABS VS TYPICAL PEPTIDE SELLER

Clear specs & documentation per product

Minimal product information

Standardized vial format and fill amount

Mixed packaging, unclear content

Practical storage & handling guidance

Practical storage & handling guidance

Lot number on every vial for traceability

Hard to trace individual batches

Fast, helpful support for docs & orders

Slow or generic customer support

Everything You Need to Know!

Frequently Asked Questions

A sterile, sealed vial containing a defined amount of lyophilized peptide, labeled with product name and lot number.

Yes. A COA is available for every lot and can be requested from our support team.

Each batch is analyzed using established methods (e.g. HPLC, MS) to confirm identity and purity as stated on the COA.

Store unopened vials in a refrigerator (2–8 °C), protected from light and moisture, unless otherwise indicated on the product label.

No. All MB1 Labs products are supplied strictly as laboratory reagents for research use only and are not intended for human or veterinary use, diagnostics, or therapy.


  • Third-party tested

    Independent analytical testing to verify identity and purity of each batch.

  • COAs FOR EVERY LOT

    Comprehensive Certificates of Analysis available for all released batches.

  • RESEARCH-ONLY USE

    Supplied strictly as laboratory reagents – not for human or veterinary use.

  • CONTROLLED HANDLING

    Standardized storage and handling to help preserve compound integrity.