MB1 Labs Peptides

Nootropic Heptapeptide

The BDNF Amplifier: A Synthetic ACTH Fragment for Brain Research

Semax is a synthetic heptapeptide derived from the 4-10 fragment of adrenocorticotropic hormone (ACTH). Originally developed in Russia for stroke treatment, it has demonstrated remarkable effects on brain-derived neurotrophic factor (BDNF), serotonin, and dopamine levels. Unlike ACTH itself, Semax exhibits potent neurotropic and neuroprotective properties without affecting cortisol or the adrenal axis — making it a uniquely focused tool for cognitive and neurological research.

  • Synthetic heptapeptide: Met-Glu-His-Phe-Pro-Gly-Pro
  • Derived from ACTH (amino acids 4-10)
  • Elevates BDNF, serotonin, and dopamine
  • No effect on cortisol or adrenal function
  • Gene expression changes within 20 minutes
Default Mode Network & Neuroplasticity

How Semax Rewires the Resting Brain

Semax uniquely activates the brain's default mode network (DMN) — the neural system responsible for environmental monitoring, social cognition, and attention switching. fMRI studies show Semax boosts DMN activity, enhancing the brain's readiness to shift from rest to focused states. This increased interconnectivity correlates with improved problem-solving, memory, and creativity. A single dose affects 24 genes related to vascular function and neuroplasticity.

  • Activates default mode network (fMRI-confirmed)
  • Enhances rest-to-focus state transitions
  • Increases brain interconnectivity
  • Modulates 24 genes for vascular/neural function
  • Rapid gene expression (hippocampus + frontal cortex)
Research Applications

From Stroke Recovery to Depression Research

Semax research spans neuroprotection, cognitive enhancement, and mood regulation. In stroke rehabilitation studies, it accelerates functional recovery and improves motor performance by elevating BDNF. Depression research suggests BDNF-stimulating peptides like Semax may explain why SSRIs take weeks to work — opening new pathways for faster-acting interventions. Additional applications include optic nerve inflammation, immune modulation, and epilepsy-related cognitive protection.

  • Stroke: Accelerates recovery, improves motor function
  • Neuroprotection: Stabilizes mitochondria, promotes neuron survival
  • Depression research: BDNF pathway insights
  • Cognitive enhancement: Learning and memory studies
  • Immune function and optic nerve inflammation

MB1 LABS VS TYPICAL PEPTIDE SELLER

Clear specs & documentation per product

Minimal product information

Standardized vial format and fill amount

Mixed packaging, unclear content

Practical storage & handling guidance

Practical storage & handling guidance

Lot number on every vial for traceability

Hard to trace individual batches

Fast, helpful support for docs & orders

Slow or generic customer support

Everything You Need to Know!

Frequently Asked Questions

A sterile, sealed vial containing a defined amount of lyophilized peptide, labeled with product name and lot number.

Yes. A COA is available for every lot and can be requested from our support team.

Each batch is analyzed using established methods (e.g. HPLC, MS) to confirm identity and purity as stated on the COA.

Store unopened vials in a refrigerator (2–8 °C), protected from light and moisture, unless otherwise indicated on the product label.

No. All MB1 Labs products are supplied strictly as laboratory reagents for research use only and are not intended for human or veterinary use, diagnostics, or therapy.


  • Third-party tested

    Independent analytical testing to verify identity and purity of each batch.

  • COAs FOR EVERY LOT

    Comprehensive Certificates of Analysis available for all released batches.

  • RESEARCH-ONLY USE

    Supplied strictly as laboratory reagents – not for human or veterinary use.

  • CONTROLLED HANDLING

    Standardized storage and handling to help preserve compound integrity.